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pentobarbital will lower the level or outcome of darifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital will lessen the level or outcome of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep away from coadministration. Strong or moderate CYP3A inducers